abstract：:The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials th...

journal_title：Calcified tissue international

authors： da Rosa WLO,da Silva TM,Galarça AD,Piva E,da Silva AF

更新日期：2019-02-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE), a chronic inflammatory disease characterized by loss of T- and B-cell tolerance to autoantigens, are at increased risk for osteoporosis and fractures. Mice deficient in Fc gamma receptor IIb (FcγRIIB) exhibit spontaneous SLE and its restoration rescues the disease. To ...

journal_title：Calcified tissue international

authors： Saiworn W,Thim-Uam A,Visitchanakun P,Atjanasuppat K,Chantaraaumporn J,Mokdara J,Chungchatupornchai S,Pisitkun P,Leelahavanichkul A,Poolthong S,Baron R,Lotinun S

更新日期：2018-12-01 00:00:00

abstract：:Observational studies examining associations of smoking and alcohol consumption with bone mineral density (BMD) have generated inconsistent results and suffer from several methodological limitations. We aim to evaluate whether there are causal associations between smoking, alcohol consumption, and BMD using a Mendelia...

journal_title：Calcified tissue international

authors： Guo R,Wu L,Fu Q

更新日期：2018-11-01 00:00:00

abstract：:There are few longitudinal data on change in bone structure and muscle mass, strength and function in later life. We report these, and consider bone-muscle interrelationships in older men and women. We studied 188 men and 166 women from the Hertfordshire Cohort Study, who underwent peripheral quantitative computed tom...

journal_title：Calcified tissue international

authors： Patel A,Edwards MH,Jameson KA,Ward KA,Fuggle N,Cooper C,Dennison EM

更新日期：2018-11-01 00:00:00

abstract：:Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...

journal_title：Calcified tissue international

authors： Xu L,Zhang L,Wang Z,Li C,Li S,Li L,Fan Q,Zheng L

更新日期：2018-10-01 00:00:00

abstract：:Regular physical activity (PA) is associated with reduced risk of the development and progression of musculoskeletal, metabolic and vascular disease. However, PA declines with age and this can contribute to multiple adverse outcomes. The aims of this study were to describe the relationship between accelerometer-determ...

journal_title：Calcified tissue international

authors： Westbury LD,Dodds RM,Syddall HE,Baczynska AM,Shaw SC,Dennison EM,Roberts HC,Sayer AA,Cooper C,Patel HP

更新日期：2018-09-01 00:00:00

abstract：:The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...

journal_title：Calcified tissue international

authors： Kemmler W,Grimm A,Bebenek M,Kohl M,von Stengel S

更新日期：2018-09-01 00:00:00

abstract：:Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in increased bone formation and mass. As both affect the same signaling pathway, we aimed to elucidate the redundancy and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab) ...

journal_title：Calcified tissue international

authors： Morse A,Cheng TL,Schindeler A,McDonald MM,Mohanty ST,Kneissel M,Kramer I,Little DG

更新日期：2018-09-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...

journal_title：Calcified tissue international

authors： Paine A,Ritchlin C

更新日期：2018-05-01 00:00:00

abstract：:The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic microorganisms living in our intestine. The GM-host interactions contribute to the maturation of the host immune system, modulating its systemic response. It is well documented that GM can interact with non-enteral cells such as immune cells,...

journal_title：Calcified tissue international

authors： D'Amelio P,Sassi F

更新日期：2018-04-01 00:00:00

abstract：:X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospectiv...

journal_title：Calcified tissue international

authors： Shanbhogue VV,Hansen S,Jørgensen NR,Beck-Nielsen SS

更新日期：2018-03-01 00:00:00

abstract：:The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...

journal_title：Calcified tissue international

authors： Minematsu A,Nishii Y,Imagita H,Sakata S

更新日期：2018-03-01 00:00:00

abstract：:Bruck syndrome is a rare autosomal recessive form of osteogenesis imperfecta (OI), which is mainly characterized by joint contractures and recurrent fragility fractures. Mutations in FKBP10 and PLOD2 were identified as the underlying genetic defects of Bruck syndrome. Here we investigated the phenotypes and the pathog...

journal_title：Calcified tissue international

authors： Lv F,Xu X,Song Y,Li L,Asan,Wang J,Yang H,Wang O,Jiang Y,Xia W,Xing X,Li M

更新日期：2018-03-01 00:00:00

abstract：:The five-year survival rate for primary bone cancers is ~ 70% while almost all cases of secondary metastatic bone cancer are terminal. Hypoxia, the deficiency of oxygen which occurs as the rate of tumour growth exceeds the supply of vascularisation, is a key promoter of tumour progression. Hypoxia-driven effects in th...

journal_title：Calcified tissue international

authors： Cox TR,Erler JT,Rumney RMH

更新日期：2018-02-01 00:00:00

abstract：:Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...

journal_title：Calcified tissue international

authors： Handforth C,D'Oronzo S,Coleman R,Brown J

更新日期：2018-02-01 00:00:00

abstract：:Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes inclu...

journal_title：Calcified tissue international

authors： Aguirre LE,Colleluori G,Dorin R,Robbins D,Chen R,Jiang B,Qualls C,Villareal DT,Armamento-Villareal R

更新日期：2017-12-01 00:00:00

abstract：:Results of previous studies suggest that children and adolescents with osteogenesis imperfecta (OI) type IV have muscle force deficits. However, muscle function remains to be objectively quantified in this population. This study aimed to assess upper and lower extremity muscle function in patients with OI type IV. It ...

journal_title：Calcified tissue international

authors： Veilleux LN,Darsaklis VB,Montpetit K,Glorieux FH,Rauch F

更新日期：2017-10-01 00:00:00

abstract：:Syndesmophyte occurrence and axial bone loss were investigated in the heterozygous Tg187 tumor necrosis factor (TNF) transgenic mouse model (Tg-huTNF) of arthritis. Female and male Tg-huTNF mice were compared to wild-type mice (WT) at 2, 4, 6, 8, and 10 weeks. Syndesmophytes, intervertebral disc space, osteoclasts, os...

journal_title：Calcified tissue international

authors： Courbon G,Flammier S,Laroche N,Vico L,Marotte H,Coury F

更新日期：2017-06-01 00:00:00

abstract：:Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone ...

journal_title：Calcified tissue international

authors： Carbone LD,Bůžková P,Fink HA,Robbins JA,Bethel M,Hamrick MW,Hill WD

更新日期：2017-06-01 00:00:00

abstract：:This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormon...

journal_title：Calcified tissue international

authors： Thornton D,Gordon CM

更新日期：2017-05-01 00:00:00

abstract：:To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DX...

journal_title：Calcified tissue international

authors： Ho-Pham LT,Lai TQ,Nguyen UD,Bui QV,Nguyen TV

更新日期：2017-01-01 00:00:00

abstract：:Duffy antigen receptor for chemokines (DARC) binds to a number of pro-inflammatory chemokines, and since chemokines are known to regulate trafficking of osteoclast (OC) precursors, we predicted that DARC would regulate OC recruitment to sites of inflammation by modulating chemokine activity. To test this hypothesis, w...

journal_title：Calcified tissue international

authors： Alemi F,Elgendy M,Edderkaoui B

更新日期：2016-11-01 00:00:00

abstract：:Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...

journal_title：Calcified tissue international

authors： Iwamoto J,Seki A,Nango N

更新日期：2016-11-01 00:00:00

abstract：:Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis, is well established. However, the effects of prolonged PTH exposure on key regulators o...

journal_title：Calcified tissue international

authors： Houston DA,Myers K,MacRae VE,Staines KA,Farquharson C

更新日期：2016-11-01 00:00:00

abstract：:High serum levels of IGFBP-1 are related both to low body mass index (BMI) and to low insulin-like growth factor 1 (IGF-I), which both in turn are related to low bone mineral density (BMD) and to increased fracture risk. However, we have found no previous prospective studies on IGFBP-1 and fracture risk. Despite its n...

journal_title：Calcified tissue international

authors： Lundin H,Sääf M,Strender LE,Nyren S,Johansson SE,Salminen H

更新日期：2016-10-01 00:00:00

abstract：:Age-related loss of skeletal muscle is associated with increased risk of functional limitation and cardiovascular (CV) mortality. In the elderly abdominal aortic calcification (AAC) can increase CV risk by altering aortic properties which may raise blood pressure and increase cardiac workload. This study investigated ...

journal_title：Calcified tissue international

authors： Rodríguez AJ,Scott D,Khan B,Khan N,Hodge A,English DR,Giles GG,Ebeling PR

更新日期：2016-10-01 00:00:00

abstract：:Low-grade inflammation negatively affects bone. Resveratrol is a natural compound proven to possess both anti-inflammatory and bone protective properties. However, it is uncertain if the bone effects are mediated though anti-inflammatory effects. Firstly, we investigated if resveratrol affects proliferation and differ...

journal_title：Calcified tissue international

authors： Ornstrup MJ,Harsløf T,Sørensen L,Stenkjær L,Langdahl BL,Pedersen SB

更新日期：2016-08-01 00:00:00

abstract：:Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...

journal_title：Calcified tissue international

authors： Marques A,Lourenço Ó,Ortsäter G,Borgström F,Kanis JA,da Silva JA

更新日期：2016-08-01 00:00:00

abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...

journal_title：Calcified tissue international

authors： Zhang D,Fong C,Jia Z,Cui L,Yao X,Yang M

更新日期：2016-08-01 00:00:00

abstract：:Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength). Based on the FRAX studies suggesting that the questions without bone mineral density can be used to screen for osteoporosis, there is now a valid simple questionnaire...

journal_title：Calcified tissue international

authors： Morley JE

更新日期：2016-04-01 00:00:00

abstract：:Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and bone archi...

journal_title：Calcified tissue international

authors： Frederiksen KD,Hanson S,Hansen S,Brixen K,Gram J,Jørgensen NR,Støving RK

更新日期：2016-03-01 00:00:00

abstract：:Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral den...

journal_title：Calcified tissue international

authors： Holmberg T,Bech M,Gram J,Hermann AP,Rubin KH,Brixen K

更新日期：2016-03-01 00:00:00

abstract：:Sclerostin and parathyroid hormones are strong negative and positive regulators of bone formation, respectively. The anabolic response induced by intermittent (iPTH) treatment is sclerostin status-dependent. However, the interaction between sclerostin and iPTH at the matrix level is unknown. The goal of the current st...

journal_title：Calcified tissue international

authors： Ross RD,Mashiatulla M,Robling AG,Miller LM,Sumner DR

更新日期：2016-02-01 00:00:00

abstract：:The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic-osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientatio...

journal_title：Calcified tissue international

authors： Shah FA,Zanghellini E,Matic A,Thomsen P,Palmquist A

更新日期：2016-02-01 00:00:00

abstract：:Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors ...

journal_title：Calcified tissue international

authors： Gulin T,Kruljac I,Kirigin L,Merc M,Pavić M,Trcin MT,Bokulić A,Megla ŽB,Kaštelan D

更新日期：2016-01-01 00:00:00

abstract：:Yerba mate (Ilex paraguariensis) is a xanthine-containing beverage, which is also rich in caffeine. Because caffeine has a negative impact on bone mineral density (BMD) mainly associated with low calcium (Ca) diets, there would be expected a negative effect of yerba mate on bone. In this study, Sprague-Dawley rats wer...

journal_title：Calcified tissue international

authors： Brun LR,Brance ML,Lombarte M,Maher MC,Di Loreto VE,Rigalli A

更新日期：2015-11-01 00:00:00

abstract：:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...

journal_title：Calcified tissue international

authors： Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

更新日期：2015-10-01 00:00:00

abstract：:Data have accumulated to show that various types of collagen crosslinking are implicated in the health of individuals, as well as in a number of disease states, such as osteoporosis, diabetes mellitus, chronic kidney disease, inflammatory bowel disease, or in conditions of mild hyperhomocysteinemia, or when glucocorti...

journal_title：Calcified tissue international

authors： Saito M,Marumo K

更新日期：2015-09-01 00:00:00

abstract：:Regular tennis play is associated with impressive asymmetries in bone strength in favor of the racquet arm, particularly in the humerus. However, the relative effects of service and ground strokes are not known. Serendipitously, we encountered a 46-year-old regular tennis player who has played service and ground strok...

journal_title：Calcified tissue international

authors： Ireland A,Degens H,Maffulli N,Rittweger J

更新日期：2015-08-01 00:00:00

abstract：:Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair. We investigated the role of Simvastatin (Sim)-embedded porous Gelapin (Gel) scaffold on exp...

journal_title：Calcified tissue international

authors： Moshiri A,Shahrezaee M,Shekarchi B,Oryan A,Azma K

更新日期：2015-06-01 00:00:00